![]() ![]() ![]() With the benefits that can be attained by switching from LLE to SLE, we wonder-why haven’t most made the switch? As a tried and true technique, LLE is around for the long haul, however several misconceptions exist that we’d like to address. SLE follows the same extraction rules as LLE and can be performed with the same solvents that one would use for LLE, making it an easy transition. This updated sample prep technique not only uses less solvent than LLE, but is quicker and less labor intensive than traditional LLE. We previously discussed how environmental labs are transforming their LLE methods to more targeted techniques, such as QuEChERS or SPE, to achieve cleaner extractions and the ability to automate in “Whatever Happened to the Shaking Party? New Technology Challenging Old Lab Traditions”.īut what about the most obvious swap from LLE? Supported Liquid Extraction (SLE) (also referred to as solid liquid extraction, solid supported liquid extraction, simplified liquid extraction, etc.) is essentially a liquid-liquid extraction using a solid supported material to perform the extraction-hence where the name comes from. How many scientists could honestly say “no” to less variability and increased reliability? Yet, time and time again, we see scientists who are content with Liquid-Liquid Extraction (LLE) as the preferred extraction method for their laboratories. ![]()
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